A METHOD FOR THE FACILE SYNTHESIS OF RING-A HYDROXYLATED FLAVONES

被引：38

作者：

CUSHMAN, M

NAGARATHNAM, D

机构：

[1] Department of Medicinal Chemistry, Pharmacognosy Purdue University, West Lafayette

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(00)97100-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method for the facile synthesis of ring-A hydroxylated flavones is described. Treatment of the hydroxylated acetophenones 6a-d with enough lithium bis(trimethyl)silyl amide to deprotonate all of the phenols as well as to generate the lithium enolate of the ketone, followed by addition of the acid chlorides 7a-d, gave the 1,3-diketones 8a-g, which were cyclized to the desired products 9a-g in high yield. © 1990.

引用

页码：6497 / 6500

页数：4

共 18 条

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