DOWN-REGULATION OF LAK CELL-MEDIATED CYTOTOXICITY - CANCER AND AGING

被引：7

作者：

BYKOVSKAYA, SN ^{[1
]}

ABRONINA, IF ^{[1
]}

KUPRIYANOVA, TA ^{[1
]}

BUBENIK, J ^{[1
]}

机构：

[1] CZECHOSLOVAK ACAD SCI, INST MOLEC GENET, CS-16637 PRAGUE 6, CZECHOSLOVAKIA

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1990年 / 44卷 / 06期

关键词：

cellules LAK / cancer / vieillissement; LAK cells / cancer / ageing;

D O I：

10.1016/0753-3322(90)90137-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A comparative study was made of the generation of lymphokine-activated killer (LAK) cells in patients with melanoma and healthy donors of different age groups. Significant reduction of effector il cytotoxicity in patients following 72_h culture with 1 000 U/ml or recombinant IL-2 (rIL-2) as well as a decreased ability to generate LAK cells in elderly individuals were shown to be correlated with suppressor cell activation in rIL-2 stimulated cell population. Suppressor effect depends on monocytes and T-lymphocytes: partial abolition of suppression in LAK cells was observed following removal of adherent cells or treatment with OKT8 monoclonal antibodies and complement. © 1990.

引用

页码：333 / 338

页数：6

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