CORTICOTROPIN-RELEASING FACTOR-LIKE IMMUNOREACTIVITY AND MESSENGER-RNA IN HUMAN-LEUKOCYTES

被引:136
作者
STEPHANOU, A [1 ]
JESSOP, DS [1 ]
KNIGHT, RA [1 ]
LIGHTMAN, SL [1 ]
机构
[1] BROMPTON HOSP,DEPT CYST FIBROSIS,LONDON SW3 6HP,ENGLAND
关键词
D O I
10.1016/0889-1591(90)90007-D
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Unstimulated normal leukocytes were studied for their expression of corticotrophin-releasing factor (CRF)-like mRNA and peptide. In situ hybridization demonstrated CRF mRNA in T and B lymphocytes and in neutrophils. Northern blot analysis also detected the presence of a CRF mRNA species of approximately 1.7 Kb from lymphocytes and a peptide that reacted with anti-CRF antiserum was also detected by radioimmunoassay. This lymphocyte-derived peptide eluted earlier than standard CRF on high performance liquid chromatography. These findings suggest that regulatory mechanisms within the hypothalamus and the immune system may utilize closely related peptides. © 1990.
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页码:67 / 73
页数:7
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