LIPOSOME-MEDIATED DELIVERY STIMULATES A CLASS-I-RESTRICTED CYTOTOXIC T-CELL RESPONSE TO SOLUBLE-ANTIGEN

被引：47

作者：

LOPES, LM

CHAIN, BM

机构：

[1] ICRF Tumour Immunology Unit, Dept. Biology, University College of London, London, WC1 6BT, Gower St

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1992年 / 22卷 / 01期

关键词：

D O I：

10.1002/eji.1830220143

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most soluble protein antigens are poor at priming class I-restricted cytotoxic cell activity. In this study we show that incorporation of one protein, ovalbumin, into liposomes converts this antigen into an effective stimulator of antigen-specific cytotoxicity. The mechanisms responsible for this phenomenon are discussed.

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页码：287 / 290

页数：4

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