ROLE OF FATTY-ACID METABOLITES IN THE DEVELOPMENT OF MYOCARDIAL ISCHEMIC DAMAGE

被引：21

作者：

HUTTER, JF

SOBOLL, S

机构：

[1] UNIV DUSSELDORF,INST PHYSIOL CHEM 1,MOORENSTR 5,W-4000 DUSSELDORF 1,GERMANY

[2] BAYER AG,INST PHARMAKOL,W-5600 WUPPERTAL 1,GERMANY

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 03期

关键词：

D O I：

10.1016/0020-711X(92)90030-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The review deals with possible mechanisms by which fatty acids amplify ischemic damage in myocardium. 2. The accumulation of free fatty acids, long chain acyl CoA and carnitine esters during hypoxia and their effects on various enzymatic systems are discussed. 3. Findings on the influence of exogenous fatty acids as well as observations concerning an inhibition of fatty acid degradation are also considered. 4. Finally the role of an oxygen steal effect, as an indirect mechanism for the fatty acid induced amplification of ischemic damage, is discussed.

引用

页码：399 / 403

页数：5

共 51 条

[1] EFFECT OF PALMITOYL CARNITINE ON NA+, K+-ATPASE AND ADENYLATE-CYCLASE ACTIVITY OF CANINE MYOCARDIAL SARCOLEMMA [J].