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FACILITATION OF COCAINE KINDLING BY GLUCOCORTICOIDS IN RATS

被引：31
作者：
KLING, MA
SMITH, MA
GLOWA, JR
PLUZNIK, D
DEMAS, J
DEBELLIS, MD
GOLD, PW
SCHULKIN, J
机构：
[1] NIMH, BIOL PSYCHIAT BRANCH, BETHESDA, MD 20892 USA
[2] NIDDKD, MED CHEM LAB, BETHESDA, MD 20892 USA
来源：
BRAIN RESEARCH | 1993年 / 629卷 / 01期
关键词：
GLUCOCORTICOID; DEXAMETHASONE; COCAINE; KINDLING; SENSITIZATION;
D O I：
10.1016/0006-8993(93)90497-B
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We report that glucocorticoids significantly facilitated the development of cocaine-induced kindled seizures. These results suggest that glucocorticoids may have effects on the development of kindled seizures which are similar to those of the neuropeptide, corticotropin-releasing hormone (CRH), with which they show a close functional relationship. These results may be of interest in the light of data showing that glucocorticoids increase CRH expression in the central nucleus of the amygdala, which is an important site for the development of kindling.
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页码：163 / 166
页数：4
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