MRI-GUIDED BIOPSY IN INFLAMMATORY MYOPATHY - INITIAL RESULTS

被引：65

作者：

PITT, AM ^{[1
]}

FLECKENSTEIN, JL ^{[1
]}

GREENLEE, RG ^{[1
]}

BURNS, DK ^{[1
]}

BRYAN, WW ^{[1
]}

HALLER, R ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT RADIOL,ALGUR H MEADOWS DIAGNOST IMAGING CTR,DALLAS,TX 75235

来源：

MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 08期

关键词：

MUSCLES; MRI; MYOSITIS; BIOPSY; MYOPATHY;

D O I：

10.1016/0730-725X(93)90236-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The purpose of this report is to describe our initial experience with techniques employing magnetic resonance imaging (MRI) to guide the choice of muscle to be biopsied in patients suspected of having inflammatory myopathy. Five patients with a clinical diagnosis of inflammatory myopathy (IM) were studied. Four were imaged prior to biopsy. Four had repeated examinations, either immediately following biopsy or to evaluate disease progression. Use of MRI to localize muscle lesions was associated with abnormal pathologic findings in all cases, including histopathologic demonstration of lymphocyte infiltration in three cases of idiopathic polymyositis; nonspecific myopathic changes were seen in one patient with probable dermatomyositis and in one patient with chronic inflammatory polyneuropathy and high serum creatine kinase levels (>45,000 IU/ml). The precise location of the area sampled by biopsy was visible in only one of four postbiopsy images. MRI shows promise in identifying pathologic muscle in patients suspected of having one of the inflammatory myopathies; however, further refinement of localization techniques may be needed to optimize histopathologic diagnoses.

引用

页码：1093 / 1099

页数：7

共 14 条

[1]

Bohan, Peter, Bowman, Pearson, A computer-assisted analysis of 153 patients with polymyositis and dermatomyositis, Medicine, 56, pp. 255-277, (1977)

[2]

Bunch, Polymyositis: A case history approach to the differential diagnosis and treatment, Mayo Clin. Proc., 65, pp. 1480-1497, (1977)

[3]

Fleckenstein, Weatherall, Bertocci, Ezaki, Haller, Greenlee, Bryan, Peshock, Locomotor system assessment by magnetic resonance imaging, Magn. Reson. Q., 7, pp. 79-103, (1990)

[4]

Fraser, Frank, Dalakas, Inflammatory Myopathies: MR imaging and spectroscopy, Radiology, 179, pp. 341-344, (1991)

[5]

Fujino, Kobayashi, Goto, Onitsuka, Magnetic resonance imaging of the muscles in patients with polymyositis and dermatomyositis, Muscle Nerve, 14, pp. 716-720, (1991)

[6]

Hernandez, Keim, Sullivan, Chenevert, Martel, Magnetic resonance imaging appearance of the muscles in childhood dermatomyositis, J. Pediatr., 117, pp. 546-550, (1990)

[7]

Kaufman, Gruber, Gerstman, Kaeli, Preliminary observations on the role of magnetic resonance imaging for polymyositis and dermatomyositis, Ann. Rheumat. Dis., 46, (1987)

[8]

Lamminen, Magnetic resonance imaging of primary skeletal muscle disease: Patterns of distribution and severity of involvement, Br. J. Radiol., 63, pp. 946-950, (1990)

[9]

Hernandez, Keim, Chenevert, Sullivan, Aisen, Fat-suppressed MR imaging in myositis, Radiology, 182, pp. 217-219, (1992)

[10]

Park, Vansant, Kumar, Gibbs, Curvin, Price, Partain, James, Dermatomyositis: Correlative MR imaging and P-31 MR spectroscopy for quantitative characterization of inflammatory disease, Radiology, 177, pp. 473-479, (1990)

← 1 2 →