ESTRADIOL STIMULATES CORTISOL PRODUCTION BY ADRENAL-CELLS IN ESTROGEN-DEPENDENT PRIMARY ADRENOCORTICAL NODULAR DYSPLASIA

被引:47
作者
CATICHA, O
ODELL, WD
WILSON, DE
DOWDELL, LA
NOTH, RH
SWISLOCKI, ALM
LAMOTHE, JJ
BARROW, R
机构
[1] UNIV CALIF DAVIS, SCH MED, DEPT INTERNAL MED, DAVIS, CA 95616 USA
[2] UNIV CALIF DAVIS, SCH MED, DEPT FAMILY PRACTICE, DAVIS, CA 95616 USA
[3] UNIV CALIF DAVIS, SCH MED, DEPT AMBULATORY FAMILY MED, DAVIS, CA 95616 USA
[4] MERRITHEW MEM HOSP, MARTINEZ, CA 94553 USA
[5] VET ADM MED CTR, MARTINEZ, CA 94553 USA
关键词
D O I
10.1210/jc.77.2.494
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adrenal glands from a patient with ACTH-independent Cushing's syndrome, whose symptoms worsened during pregnancy and oral contraceptive use, were cultured in different concentrations of estradiol. Estradiol stimulated cortisol secretion in a dose-response manner in the absence of ACTH. Since immunoglobulins G from this patient did not stimulate corticosterone production in a mouse adrenal bioassay, an adrenal-stimulating immunoglobulin is unlikely to be the cause of adrenal hyperfunction in this case. This is the first description of estradiol stimulation of cortisol production by cultured adrenal cells in ACTH-independent Cushing's syndrome.
引用
收藏
页码:494 / 497
页数:4
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