ULTRASOUND MEASUREMENT OF PLACENTAL THICKNESS TO DETECT PREGNANCIES AFFECTED BY HOMOZYGOUS ALPHA-THALASSEMIA-1

被引：52

作者：

GHOSH, A ^{[1
]}

TANG, MHY ^{[1
]}

LAM, YH ^{[1
]}

FUNG, E ^{[1
]}

CHAN, V ^{[1
]}

机构：

[1] QUEEN MARY HOSP,DEPT MED,HONG KONG,HONG KONG

来源：

LANCET | 1994年 / 344卷 / 8928期

关键词：

D O I：

10.1016/S0140-6736(94)91644-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Homozygous alpha-thalessaemia-1, a common cause of hydrops fetalis, is usually diagnosed invasively. We measured placental thickness by ultrasound at 10-21 weeks' gestation in 231 at-risk pregnancies. 60 were affected (by DNA analysis). The sensitivity and specificity in detecting affected pregnancies at cut-off of mean placental thickness plus 2 SD before 12 weeks' gestation were 0.72 (95% Cl 0.52-0.93) and 0.97 (0.9-1.0). After 12 weeks sensitivity increased to 0.95 (0.89-1.0) and by 18 weeks reached 1.0 (0.60-0.99) without change in specificity. Selection of pregnancies at risk by measurement of placental thickness will reduce the number of invasive diagnostic procedures.

引用

页码：988 / 989

页数：2

共 10 条

[1] PRENATAL-DIAGNOSIS OF HOMOZYGOUS ALPHA-THALASSEMIA BY DIRECT DNA ANALYSIS OF UNCULTURED AMNIOTIC-FLUID CELLS [J].