POTENTIATION OF N-METHYL-D-ASPARTATE RECEPTOR-DEPENDENT AFTERDISCHARGES IN RAT DENTATE GYRUS FOLLOWING IN-VITRO ETHANOL WITHDRAWAL

被引：20

作者：

MORRISETT, RA

机构：

[1] Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE 68198-6260

来源：

NEUROSCIENCE LETTERS | 1994年 / 167卷 / 1-2期

关键词：

ETHANOL; ALCOHOL WITHDRAWAL; NMDA; GLUTAMATE; D-APV; EPILEPSY; AFTERDISCHARGE;

D O I：

10.1016/0304-3940(94)91055-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-D-aspartate (NMDA) receptor antagonists. Ethanol (75 mM) inhibited ADs, and following in vitro ethanol withdrawal, the duration of afterdischarges was significantly enhanced (37 +/- 2%, n = 21). Therefore, in vitro ethanol exposure with subsequent withdrawal is associated with an enhancement of NMDA receptor-dependent afterdischarges. These results are consistent with the involvement of NMDA receptors in ethanol withdrawal hyperexcitability.

引用

页码：175 / 178

页数：4

共 16 条

[1] LONG-TERM POTENTIATION OF NMDA RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS [J].