CONTROL OF INFECTION WITH MULTIPLE ANTIBIOTIC-RESISTANT BACTERIA IN A HOSPITAL RENAL UNIT - THE VALUE OF PLASMID CHARACTERIZATION

被引：8

作者：

REED, CS ^{[1
]}

BARRETT, SP ^{[1
]}

THRELFALL, EJ ^{[1
]}

CHEASTY, T ^{[1
]}

机构：

[1] CENT PUBL HLTH LAB,DIV ENTER PATHOGENS,LONDON NW9 5HT,ENGLAND

来源：

EPIDEMIOLOGY AND INFECTION | 1995年 / 115卷 / 01期

关键词：

D O I：

10.1017/S095026880005812X

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

An outbreak of infections due to multiple antibiotic-resistant bacteria took place over a period of approximately 18 months in a renal unit. Strains of Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Citrobacter spp. and Pseudomonas spp, were involved, and a variety of antibiotic resistances was encountered. Closely related plasmids encoding resistance to aztreonam, ceftazidime and piperacillin, possibly derived from an archetypal plasmid of 105 kb were found in the majority of isolates examined. After limiting the use of aztreonam the incidence of new patient isolates of multiple-resistant organisms was greatly reduced. This study demonstrated how molecular studies can contribute to the control of an outbreak situation in a hospital unit by providing an impetus to reduce the use of specific antibiotics.

引用

页码：61 / 70

页数：10

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