The effect of sub-antimicrobial dose-doxycycline periodontal therapy on serum inflammatory biomarker C-reactive protein levels in post-menopausal Women: A 2-year, double-blinded, randomized clinical trial

被引：5

作者：

Koppikar, Rajesh S. ^{[1
]}

Agrawal, Sneh V. ^{[2
]}

机构：

[1] Bharati Vidyapeeth Dent Coll & Hosp, Dept Periodontol, Sangli, India

[2] Bharati Vidyapeeth, Dent Coll & Hosp, Dept Periodontol, Navi Mumbai, Maharashtra, India

来源：

CONTEMPORARY CLINICAL DENTISTRY | 2013年 / 4卷 / 01期

关键词：

C-reactive protein; coronary artery disease; periodontitis; sub-antimicrobial dose-doxycycline;

D O I：

10.4103/0976-237X.111628

中图分类号：

R78 [口腔科学];

学科分类号：

1003 [口腔医学];

摘要：

Background: Periodontitis has been reported to be associated with coronary artery disease. Research is needed to determine whether therapies that improve periodontal health also reduce systemic marker of inflammation associated with both diseases. Aim: To determine whether sub-antimicrobial dose-doxycycline (SDD) therapy can reduce systemic serum inflammatory biomarker C-reactive protein (CRP) in post-menopausal women who have chronic periodontitis. Settings and Design: The study randomly assigned 128 eligible post-menopausal women with chronic periodontitis to a 90-day, twice-daily regimen of SDD or placebo tablets evaluated for 2 years, as an adjunct to periodontal maintenance therapy. Materials and Methods: The study assayed blood samples for inflammatory mediators at baseline, 1 year, and 2 years. CRP was measured using a high-sensitivity enzyme-linked immunosorbent assay. Results: SDD treatment reduced median high-sensitivity CRP by 18% (primary outcome = 0.02). Conclusion: Ninety-day SDD regimen in post-menopausal women significantly reduced the serum inflammatory biomarker CRP over a 2-year period.

引用

页码：71 / 73

页数：3

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