MUTAGENICITY OF METABOLICALLY ACTIVATED BENZO[A]ANTHRACENE 3,4-DIHYDRODIOL - EVIDENCE FOR BAY REGION ACTIVATION OF CARCINOGENIC POLYCYCLIC-HYDROCARBONS

被引：112

作者：

WOOD, AW

LEVIN, W

LU, AYH

RYAN, D

WEST, SB

LEHR, RE

SCHAEFERRIDDER, M

JERINA, DM

CONNEY, AH

机构：

[1] HOFFMANN LA ROCHE INC,DEPT BIOCHEM & DRUG METAB,NUTLEY,NJ 07110

[2] NIAMDD,OXIDATION MECH SECT,CHEM LAB,BETHESDA,MD 20014

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1976年 / 72卷 / 02期

关键词：

D O I：

10.1016/S0006-291X(76)80093-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：680 / 686

页数：7

共 20 条

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BORGEN, A ;

DARVEY, H ;

CASTAGNO.N ;

CROCKER, TT ;

RASMUSSE.RE ;

WANG, IY .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (05) :502-506

[2]

CONNEY AH, 1976, REACTIVE INTERMEDIAT

[3] IDENTIFICATION OF MUTAGENIC METABOLITES OF BENZO[A]PYRENE IN MAMMALIAN-CELLS [J].

HUBERMAN, E ;

SACHS, L ;

YANG, SK ;

GELBOIN, HV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (02) :607-611

[4]

JERINA DM, 1976, ACTIVATION MUTAGENES

[5]

JERINA DM, 1976, DRUG METABOLISM, P15

[6]

JERINA DM, 1976, POLYNUCLEAR AROMATIC, P91

[7]

LEHR RE, IN PRESS

[8] CARCINOGENICITY OF BENZO[A]PYRENE 4,5-OXIDES, 7,8-OXIDES AND 9,10-OXIDES ON MOUSE SKIN [J].

LEVIN, W ;

WOOD, AW ;

YAGI, H ;

DANSETTE, PM ;

JERINA, DM ;

CONNEY, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (01) :243-247

[9]

LEVIN W, 1974, J BIOL CHEM, V249, P1747

[10]

LEVIN W, IN PRESS

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