NITRIC-OXIDE SYNTHASE IN CARDIAC NERVE-FIBERS AND NEURONS OF RAT AND GUINEA-PIG HEART

被引：203

作者：

KLIMASCHEWSKI, L

KUMMER, W

MAYER, B

COURAUD, JY

PREISSLER, U

PHILIPPIN, B

HEYM, C

机构：

[1] GRAZ UNIV,INST PHARMACOL & TOXICOL,A-8010 GRAZ,AUSTRIA

[2] CENS,PHARMACOL & IMMUNOL SECT,F-91190 GIF SUR YVETTE,FRANCE

来源：

CIRCULATION RESEARCH | 1992年 / 71卷 / 06期

关键词：

NITRIC OXIDE; HEART; INNERVATION;

D O I：

10.1161/01.RES.71.6.1533

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Participation of nitric oxide (NO) in the autonomic innervation of rat and guinea pig hearts was investigated by applying the NADPH diaphorase technique and immunohistochemistry with NO synthase antiserum. We present evidence that NO synthase is localized in cardiac ganglion cells and nerve fibers innervating the sinuatrial and atrioventricular nodes, the myocardium, local neurons, coronary arteries, and pulmonary vessels, suggesting an involvement of NO in neurogenic heart rate regulation, myocardial cell function, neuronal transmission in cardiac ganglia, and coronary as well as pulmonary vasodilation.

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页码：1533 / 1537

页数：5

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