TRYPANOSOMA-BRUCEI IS PROTECTED FROM THE CYTOSTATIC EFFECTS OF NITRIC-OXIDE UNDER IN-VIVO CONDITIONS

被引：42

作者：

MABBOTT, NA ^{[1
]}

SUTHERLAND, IA ^{[1
]}

STERNBERG, JM ^{[1
]}

机构：

[1] UNIV ABERDEEN,DEPT ZOOL,ABERDEEN AB9 2TN,SCOTLAND

来源：

PARASITOLOGY RESEARCH | 1994年 / 80卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1007/BF00932954

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In mice infected with Trypanosoma brucei, splenic and peritoneal macrophages release substantial amounts of nitric oxide (NO). The production of NO by activated macrophages has been reported to be a nonspecific immune-effector mechansism against several parasites, and in this work we investigate the role of NO in killing T. brucei. Addition of bloodstream trypanosomes to peritoneal macrophages activated in vitro resulted in an NO-dependent inhibition of parasite growth. This effect was totally abrogated when dilutions of whole blood were included in the cultures, suggesting that bloodstream parasites such as T. brucei are not susceptible to NO-mediated killing in vivo.

引用

页码：687 / 690

页数：4

共 23 条

[1]

ADAMS LB, 1990, J IMMUNOL, V144, P2725

[2]

ANTHONY LSD, 1992, J IMMUNOL, V148, P1829

[3]

ASKONAS BA, 1985, CURR TOP MICROBIOL, V117, P119

[4] CULTIVATION IN A SEMI-DEFINED MEDIUM OF ANIMAL INFECTIVE FORMS OF TRYPANOSOMA-BRUCEI, TRYPANOSOMA-EQUIPERDUM, TRYPANOSOMA-EVANSI, TRYPANOSOMA-RHODESIENSE AND T-GAMBIENSE [J].