TOTALLY SYNTHETIC ANALOGS OF SIASTATIN-B .2. OPTICALLY-ACTIVE PIPERIDINE-DERIVATIVES HAVING TRIFLUOROACETAMIDE AND HYDROXYACETAMIDE GROUPS AT C-2

Siastatin B analogues, optically active 2-(trifluoroacetamide)-3,4,5-trihydroxypiperidines having nitromethyl, aminomethyl and carboxyl branched groups at C-5, and (+)-(2R,3R,4R,5R)-5-(aminomethyl)-3,4,5-trihydroxy-2-(hydroxyacetamido)piperidine have been obtained total synthetically from D-ribono-1,4-lactone. Some analogues have inhibitory activity against some glycosidases, and (+)-(2R,3R,4R,5R)-2-(trifluoroacetamido)-3,4,5-trihydroxypiperidine-5-carboxylic acid showed a marked inhibitory activity against beta-glucuronidase.