CLONING AND CHARACTERIZATION OF THE ENTIRE CDNA ENCODED BY ATP1AL1 - A MEMBER OF THE HUMAN NA,K/H,K-ATPASE GENE FAMILY

被引：67

作者：

GRISHIN, AV ^{[1
]}

SVERDLOV, VE ^{[1
]}

KOSTINA, MB ^{[1
]}

MODYANOV, NN ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,SHEMYAKIN & OVCHINNIKOV INST BIOORGAN CHEM,MOSCOW 117871,RUSSIA

来源：

FEBS LETTERS | 1994年 / 349卷 / 01期

关键词：

NA; K-ATPASE; H; GENE FAMILY; CDNA SEQUENCE;

D O I：

10.1016/0014-5793(94)00655-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cDNA for ATP1AL1 - the fifth member of the human Na,K-/H,K-ATPase gene family - was cloned and sequenced. The deduced primary ATP1AL1 translation product is 1,039 amino acids in length and has M(r) of 114,543. The encoded protein has all of the structural features common to known catalytic subunits of P-type membrane ion-transporting ATPases and is equally distant (63-64% of identity) from the Na,K-ATPase isoforms and the gastric H,K-ATPase. The ATP1AL1 encoded protein was proposed to represent a new separate group within the family of human potassium-dependent ion pumps.

引用

页码：144 / 150

页数：7

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