APPARENT CONTENT CURVES - A METHOD TO RESOLVE SPECTRAL INTERFERENCES IN SAMPLES WITH N-COMPONENTS

A mathematical method that permits the determination of an analyte in the presence of n interferents was developed. In order to apply the method it is not necessary to know the nature and/or the number of interferents. The proposed procedure is based on obtaining the apparent content curves for the samples and the determination of the analyte may be carried out in the same way as for binary mixtures. The procedure was applied to the determination of theophylline in anti-asthmathic pharmaceutical products and good results were obtained in all instances.