STRUCTURES OF FOLDING INTERMEDIATES

被引：223

作者：

PTITSYN, OB ^{[1
]}

机构：

[1] NCI,MATH BIOL LAB,BETHESDA,MD 20892

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/0959-440X(95)80011-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past year has yielded important results in the study of protein-folding intermediates. It has been shown that the equilibrium molten globule has a native-like tertiary fold and is separated from the unfolded state by a first-order phase transition. New equilibrium intermediates have been revealed and substantial progress has been made in the understanding of two main barriers in protein folding.

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页码：74 / 78

页数：5

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