ONTOGENESIS OF THE RABBIT INTESTINAL RECEPTOR FOR 1,25-DIHYDROXYVITAMIN D3 - EVIDENCE FOR INCREASED RECEPTOR CONTENT DURING LATE SUCKLING AND LACTATING PERIODS

被引：7

作者：

DUNCAN, WE ^{[1
]}

WALSH, PG ^{[1
]}

KOWALSKI, MA ^{[1
]}

HADDAD, JG ^{[1
]}

机构：

[1] UNIV PENN, DEPT MED, PHILADELPHIA, PA 19104 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY | 1984年 / 78卷 / 02期

关键词：

D O I：

10.1016/0300-9629(84)90156-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) intestinal receptor was not detected in term fetal rabbits. This receptor was present at 2 wk postpartum and its concentration reached a maximum at 4 wk of age, and declined to adult levels by 10 wk postpartum. The 1,25(OH)2D3 intestinal receptor concentration was elevated at 2 wk postpartum in lactating rabbits, but returned to normal adult concentrations by 4 wk postpartum. In rabbits of various ages, only minor changes in the equilibrium dissociation constant of this receptor were observed. The data indicate that increasing the small intestine 1,25(OH)2D3 receptor concentration is one mechanism by which the rabbit adapts to periods of increased Ca demand.

引用

页码：333 / 336

页数：4

共 17 条

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