PROTEIN KINASE-C DURING DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKEMIA-CELL LINE, HL-60

被引：76

作者：

HASHIMOTO, K

KISHIMOTO, A

AIHARA, H

YASUDA, I

MIKAWA, K

NISHIZUKA, Y

机构：

[1] Department of Biochemistry, Kobe University School of Medicine, Kobe

来源：

FEBS LETTERS | 1990年 / 263卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

(HL-60 cells); Differentiation; Protein kinase C; Retinoic acid;

D O I：

10.1016/0014-5793(90)80698-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinase C (PKC) from human promyelocytic leukemia HL-60 cells can be resolved into three fractions (peak a, b and c) by hydroxyapatite column chromatography. Peak a and c enzymes are indistinguishable from the brain type II PKC having β (βI and βII)-sequence and type III having α-sequence, respectively. Peak b enzyme is a previously unidentified PKC subspecies that has enzymological properties subtly different from type I (having γ-sequence), type II and type III PKC. Upon treatment of HL-60 cells with 1 μM retinoic add, this peak b enzyme is decreased dramatically within 24 h, whilst peak a enzyme (β-PKC) is increased, and peak c (α-PKC) enzyme is slightly decreased within 48 h. The result implies that the PKC subspecies in HL-60 cells have distinct functions during cell differentiation. © 1990.

引用

页码：31 / 34

页数：4

共 20 条

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