CHARACTERIZATION OF A PORCINE CD1-SPECIFIC MAB THAT DISTINGUISHES CD4/CD8 DOUBLE-POSITIVE THYMIC FROM PERIPHERAL LYMPHOCYTES-T

被引：50

作者：

PESCOVITZ, MD

HSU, SM

KATZ, SI

LUNNEY, JK

SHIMADA, S

SACHS, DH

机构：

[1] IMMUNOL BRANCH, BETHESDA, MD USA

[2] DERMATOL BRANCH, BETHESDA, MD USA

[3] UNIV TEXAS, DEPT PATHOL & LAB MED, AUSTIN, TX 78712 USA

[4] HELMINTH DIS LAB, BELTSVILLE, MD USA

来源：

TISSUE ANTIGENS | 1990年 / 35卷 / 04期

关键词：

D O I：

10.1111/j.1399-0039.1990.tb01772.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Abstract: Porcine peripheral T‐cells bear CD4 and CD8 cell surface antigens that distinguish helper from cytotoxic T‐cells. In distinction from what has been found in other species, a large percentage of peripheral T‐cells simultaneously express both CD4 and CD8. Monoclonal antibody 76‐7‐4 was found to stain all cortical and 7 ± 3% of medullary thymocytes, Ia+ epidermal cells (i.e. Langerhans cells), no peripheral T‐cells and 50% of peripheral B‐cells. The antigen detected appears analogous to human CD1. All cortical thymocytes were also stained with CD4 and CD8 mAb. Since 76‐7‐4 did not stain peripheral T‐cells, we conclude that CD4/CD8 dual‐expressing peripheral T‐cells are not simply immature thymic emigrants. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：151 / 156

页数：6

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