IMIDAZO[1,2-B]PYRIDAZINES .9. SYNTHESES AND CENTRAL-NERVOUS-SYSTEM ACTIVITIES OF SOME 3-ALKOXY-6-(ORTHO-ALKOXY-PHENOXY, ORTHO-METHYLTHIO-PHENOXY OR ORTHO-FLUORO-PHENOXY)-2-ARYLIMIDAZO[1,2-B]PYRIDAZINES

被引：8

作者：

BARLIN, GB ^{[1
]}

DAVIES, LP ^{[1
]}

IRELAND, SJ ^{[1
]}

KHOO, CLY ^{[1
]}

NGUYEN, TMT ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,RES SCH BIOL SCI,VISUAL SCI GRP,CANBERRA,ACT 2601,AUSTRALIA

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1990年 / 43卷 / 03期

关键词：

D O I：

10.1071/CH9900503

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Syntheses are reported for a series of 6-(o-methoxy-, o-ethoxy-, o-methylthio- and o-fluoro- phenoxy)-3-(methoxy and ethoxy)-2-phenyl(substituted phenyl and pyridin-3″-yl)imidazo[l, 2- b]pyridazines. 1C50 values are reported for the displacement of 3H-diazepam from rat brain membrane by each of these compounds. The most active compounds were found to be 3-ethoxy-2-(p-fluorophenyl)-6-(o-methoxyphen- oxy)-, 3-methoxy-6-(o-methoxyphenoxy)-2-(m-nitrophenyl) and 3-methoxy-6-(o-methoxyphen- oxy)-2-(3″, 4″-methylenedioxy)imidazo[l, 2-b]pyridazines with 1C50 values of 15, 18 and 19 nM respectively. © 1990 ASEG.

引用

页码：503 / 510

页数：8

共 17 条

[1] COMPOUNDS FOR CANCER STUDIES
BAHNER, CT
BARCLAY, LR
BIGGERSTAFF, G
BILANCIO, DE
BLANC, GW
CLOSE, M
ISENBERG, MM
PACE, E
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1953, 75 (19) : 4838 - 4839
[2] IMIDAZO[1,2-B]PYRIDAZINES .4. SYNTHESES AND CENTRAL NERVOUS-SYSTEM ACTIVITIES OF SOME 3-METHOXY-6-PHENOXY(SUBSTITUTED PHENOXY AND NAPHTHYLOXY)-2-PHENYLIMIDAZO[1,2-B]PYRIDAZINES
BARLIN, GB
DAVIES, LP
NGU, MML
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1988, 41 (11) : 1735 - 1742
[3] IMIDAZO[1,2-B]PYRIDAZINES .6. SYNTHESES AND CENTRAL NERVOUS-SYSTEM ACTIVITIES OF SOME 6-(ALKOXY-PHENOXY AND METHYLTHIO-PHENOXY AND METHOXYBENZYLTHIO)-3-METHOXY-2-PHENYL(SUBSTITUTED PHENYL AND PYRIDINYL)IMIDAZO[1,2-B]PYRIDAZINES
BARLIN, GB
DAVIES, LP
IRELAND, SJ
NGU, MML
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1989, 42 (10) : 1735 - 1748
[4] IMIDAZO[1,2-B]PYRIDAZINES .3. SYNTHESES AND CENTRAL NERVOUS-SYSTEM ACTIVITIES OF SOME 6-CHLORO-3-METHOXY (AND ETHOXY)-2-ARYL (AND HETEROARYL)IMIDAZO[1,2-B]PYRIDAZINES
BARLIN, GB
DAVIES, LP
NGU, MML
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1988, 41 (08) : 1149 - 1156
[5] SYNTHESIS AND HYPOGLYCEMIC ACTIVITY OF PHENACYLTRIPHENYLPHOSPHORANES AND PHOSPHONIUM SALTS
BLANK, B
DITULLIO, NW
DEVINEY, L
ROBERTS, JT
SAUNDERS, HL
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (09) : 952 - 954
[6] SYNTHESIS OF SOME NEW TRIARYLETHYLENE GLYCOLS AND ATTEMPTS TO OXIDIZE THESE TO ALPHA-ARYLBENZOINS
EASTHAM, JF
FEENEY, DJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1958, 23 (12) : 1826 - 1829
[7] FODER CE, 1949, J AM CHEM SOC, V71, P1045
[8] ITAI T, 1962, CHEM PHARM BULL, V10, P936
[9] On formalin II
Karrer, P
Musante, C
[J]. HELVETICA CHIMICA ACTA, 1935, 18 : 1140 - 1143
[10] KAWAI S, 1938, B CHEM SOC JPN, V13, P480

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