THE EFFECTS OF FELODIPINE IN ANGINA-PECTORIS

被引：9

作者：

LORIMER, AR ^{[1
]}

MACFARLANE, P ^{[1
]}

PRINGLE, S ^{[1
]}

BARBOUR, MP ^{[1
]}

FOX, Y ^{[1
]}

LAWRIE, TDV ^{[1
]}

机构：

[1] ASTRA CLIN RES UNIT,EDINBURGH,SCOTLAND

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 38卷 / 05期

关键词：

Angina pectoris; exercise capacity; felodipine;

D O I：

10.1007/BF02336676

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The clinical response to felodipine, in addition to a beta-blocker, was evaluated and compared with placebo in this double-blind cross-over study. Twenty patients with exertional angina pectoris completed the study. Felodipine reduced the number of angina attacks and the Glyceryl Trinitrate (GTN) consumption. The median exercise capacity was increased 33% after 4 weeks' felodipine treatment compared with placebo. At maximal exercise, systolic blood pressure and rate pressure product were reduced by felodipine while no change was seen in heart rate or ST-depression. Felodipine reduced both supine and erect blood pressure. The mean supine blood pressure at rest was 138/82 mm Hg after four weeks' placebo treatment compared with 114/71 mm Hg after felodipine 5-10 mg b.i.d. Felodipine has overall a modest but significant antianginal benefit when combined with a beta-blocker. © 1990 Springer-Verlag.

引用

页码：415 / 419

页数：5

共 16 条

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