CALCIUM-CHANNEL ANTAGONIST EFFECTS OF SPIRONOLACTONE, AN ALDOSTERONE ANTAGONIST

被引：18

作者：

MIRONNEAU, J

机构：

[1] Cellular Physiology and Molecular Pharmacology Laboratory, Centre National de la Recherche Scientifique, Bordeaux

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1990年 / 65卷 / 23期

关键词：

D O I：

10.1016/0002-9149(90)91267-A

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of spironolactone on the contractility of vascular smooth muscle cells and on calcium channel currents of isolated cells was investigated using the patch-clamp method. Concentrations of 10 and 60 μM of spironolactone resulted in 50 and 100% inhibition, respectively, of isometric contractions. Whereas fast calcium channel current was essentially unaffected by spironolactone, stow calcium channel current was inhibited 50% by 5 to 7 μM concentrations of the drug. These results suggest that spironolactone acts on stow calcium channels in a manner similar to that of calcium blockers. © 1990.

引用

页码：K7 / K8

页数：2

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