CHANGE IN ALPHA-KETOGLUTARATE DEHYDROGENASE COOPERATIVE PROPERTIES DUE TO DIHYDROLIPOATE AND NADH

被引：25

作者：

BUNIK, VI

BUNEEVA, OA

GOMAZKOVA, VS

机构：

[1] Department of Biochemistry, Moscow State University, Moscow

来源：

FEBS LETTERS | 1990年 / 269卷 / 01期

关键词：

Cooperativity; Dihydrolipoate; NADH; α-Ketoglutarate dehydrogenase;

D O I：

10.1016/0014-5793(90)81166-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reducing 2 SH-groups of KGD by dihydrolipoate leads to cooperativity in substrate binding. Cooperative properties of KGD in the KGD complex are modulated by NADH. Physiological significance of these observations is discussed. © 1990.

引用

页码：252 / 254

页数：3

共 13 条

[1] BUNIK V I, 1985, Biokhimiya, V50, P1668
[2] BUNIK VI, 1989, BIOCHEM INT, V18, P561
[3] BUNIK VI, 1990, IN PRESS BIOCH INT
[4] GILBERT HF, 1984, METHOD ENZYMOL, V107, P330
[5] GOMAZKOVA V S, 1987, Biokhimiya, V52, P1144
[6] GOMAZKOVA VS, 1981, DOKL AKAD NAUK SSSR+, V259, P477
[7] GOMAZKOVA VS, 1985, BIOCHEM INT, V10, P917
[8] THE COMPOSITION OF THE KETOGLUTARATE DEHYDROGENASE COMPLEX
MASSEY, V
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1960, 38 (03) : 447 - 460
[9] SEVERIN S E, 1978, Biokhimiya, V43, P2241
[10] SEVERIN SE, 1974, DOKL AKAD NAUK SSSR+, V218, P719

← 1 2 →