MEASUREMENT OF BRAIN PHOSPHOINOSITIDE METABOLISM IN BIPOLAR PATIENTS USING INVIVO P-31-MRS

被引：83

作者：

KATO, T ^{[1
]}

SHIORI, T ^{[1
]}

TAKAHASHI, S ^{[1
]}

INUBUSHI, T ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI,MOLEC NEUROBIOL RES CTR,OTSU,SHIGA 52021,JAPAN

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1991年 / 22卷 / 04期

关键词：

BIPOLAR AFFECTIVE DISORDER; MAGNETIC RESONANCE SPECTROSCOPY; LITHIUM; INOSITOL PHOSPHATE; PHOSPHOINOSITIDE;

D O I：

10.1016/0165-0327(91)90064-Y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In vivo phosphorus-31 magnetic resonance spectroscopy (P-31-MRS) was used to measure phosphorus metabolism in the brains of manic patients treated with lithium carbonate. The phosphomonoester (PME) peak was elevated in the manic state in patients with DSM-IIIR bipolar disorder compared to the euthymic state and to drug-free normal controls. Elevation of the PME peak may be caused by lithium-induced accumulation of inositol 1-phosphate in the brain.

引用

页码：185 / 190

页数：6

共 19 条

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