IMMUNE SYSTEM-ASSOCIATED ANTIGENS ON THE SURFACE OF PERIPHERAL-BLOOD LYMPHOCYTES IN PATIENTS WITH ALZHEIMERS-DISEASE

被引：31

作者：

IKEDA, T

YAMAMOTO, K

TAKAHASHI, K

YAMADA, M

机构：

[1] Department of Neuropsychiatry, Yamaguchi University School of Medicine, Kogushi

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1991年 / 83卷 / 06期

关键词：

ALZHEIMERS DISEASE; LYMPHOCYTE; IMMUNE SYSTEM; ANTIGEN;

D O I：

10.1111/j.1600-0447.1991.tb05573.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We investigated the immune-associated antigens of peripheral lymphocytes from 13 patients with Alzheimer's disease (AD) and 13 age-matched healthy control subjects using two-color analysis with flow cytometry. Four ratios of immune-related antigens, T/B lymphocytes, CD4/CD8, CD4/CD45R and CD4/HLA-DR, were compared for the AD and control groups. The T/B and CD4/CD8 ratios did not differ between the groups, the ratio of CD4+CD45R+ subset in the AD group was lower than the ratio in the control group, and the ratios of CD4+CD45R- and CD4+HLA-DR+ subsets in the AD group were significantly higher. Further, in the AD group, the CD4+CD45R+/CD4+ ratio was lower and the CD4+CD45R-/CD4+ ratio was higher than in the control group.

引用

页码：444 / 448

页数：5

共 21 条

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