RESPONSES OF LATERAL HYPOTHALAMIC NEURONS RECORDED INVITRO TO MODERATE CHANGES IN GLUCOSE-CONCENTRATION

被引：16

作者：

ORSINI, JC ^{[1
]}

ARMSTRONG, DL ^{[1
]}

WAYNER, MJ ^{[1
]}

机构：

[1] UNIV TEXAS,DIV LIFE SCI,SAN ANTONIO,TX 78249

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 29卷 / 3-4期

关键词：

LATERAL HYPOTHALAMUS; GLUCOSE; BRAIN SLICE; UNIT NEURONAL ACTIVITY;

D O I：

10.1016/0361-9230(92)90089-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Single unit neuronal activity of lateral hypothalamic neurons was recorded extracellularly in hypothalamic slices. Glucose concentration in the perfusate was modified in small amounts to simulate normal physiological glycemic fluctuations associated with feeding. Several neurons responded reliably under these conditions. These data on simulated small glycemic changes, based on observations in the whole animal, suggest that the modulation of neuronal activity reported in this study is a result of a direct action of glucose on cells in this region of the hypothalamus.

引用

页码：503 / 505

页数：3

共 17 条

[1]

ARMSTRONG DL, 1986, NEUROTOXICOL TERATOL, V8, P637

[2] GLUCOSE-INDUCED EXCITATION OF HYPOTHALAMIC NEURONS IS MEDIATED BY ATP-SENSITIVE K+ CHANNELS [J].