NITRIC-OXIDE SYNTHASE IN THE RAT ANTERIOR-PITUITARY GLAND AND THE ROLE OF NITRIC-OXIDE IN REGULATION OF LUTEINIZING-HORMONE SECRETION

被引：259

作者：

CECCATELLI, S ^{[1
]}

HULTING, AL ^{[1
]}

ZHANG, X ^{[1
]}

GUSTAFSSON, L ^{[1
]}

VILLAR, M ^{[1
]}

HOKFELT, T ^{[1
]}

机构：

[1] KAROLINSKA HOSP,DEPT ENDOCRINOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 23期

关键词：

GAS; HORMONES; PULSATILE SECRETION; AUTOCRINE; GONADECTOMY;

D O I：

10.1073/pnas.90.23.11292

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

By using immunobistochemistry and in situ hybridization, we have demonstrated that the nitric oxide (NO)-synthesizing enzyme NO synthase is present in gonadotrophs and in folliculo-stellate cells of the anterior pituitary gland of male and female rats. A marked increase in levels of NO synthase protein and mRNA was observed after gonadectomy. In vitro studies on dispersed anterior pituitary cells suggest that NO inhibits gonadotropin-releasing-hormone-stimulated luteinizing hormone release. An inhibitory effect of NO has also been shown on growth-hormone-releasing-hormone-stimulated release of growth hormone [Kato, M. (1992) Endocrinology 131, 2133-2138]. Thus these findings support a dual mechanism for NO in the control of anterior pituitary hormone secretion, an autocrine mediation of luteinizing hormone release on gonadotrophs, and a paracrine effect on growth hormone secretion involving folliculo-stellate cells closely related to somatotrophs. We speculate that NO may participate in producing the pulsatile secretion patterns of these two pituitary hormones.

引用

页码：11292 / 11296

页数：5