INCREASED EXPRESSION OF C1Q RECEPTORS ON NEUTROPHILS FROM INFLAMMATORY JOINT FLUIDS

被引：9

作者：

CROCKARD, AD ^{[1
]}

THOMPSON, JM ^{[1
]}

MALHOTRA, R ^{[1
]}

MCNEILL, TA ^{[1
]}

机构：

[1] UNIV OXFORD, DEPT BIOCHEM, MRC, IMMUNOCHEM UNIT, OXFORD, ENGLAND

来源：

IMMUNOLOGY LETTERS | 1993年 / 36卷 / 02期

关键词：

ARTICULAR DISEASE; CLQ RECEPTORS; FLOW CYTOMETRY; INFLAMMATORY JOINT FLUIDS; NEUTROPHIL;

D O I：

10.1016/0165-2478(93)90052-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clq receptor (C1qR) expression was determined by immunofluorescence flow cytometry on neutrophils from paired peripheral blood and synovial fluid samples from 21 patients with rheumatoid arthritis (RA) and 13 patients with other articular diseases (OAD). In both patient groups the levels of C1qR on circulating neutrophils were similar to that observed for normal control subjects, whereas on synovial fluid neutrophils significantly higher levels of receptor expression were observed. The mean percentage increases observed were: RA patients 47%, OAD patients 72%. Clq-bearing immune complexes were most prevalent in patients with RA, with the highest concentrations being found in synovial fluid samples. No correlation between immune complex levels and neutrophil C1qR expression was noted. Upregulation of C1qR expression is a feature of activated neutrophils from inflammatory joint fluids.

引用

页码：195 / 202

页数：8

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