CONSEQUENCES OF IGE/CD23-MEDIATED ANTIGEN PRESENTATION IN ALLERGY

被引：94

作者：

MUDDE, GC ^{[1
]}

BHEEKHA, R ^{[1
]}

BRUIJNZEELKOOMEN, CAFM ^{[1
]}

机构：

[1] UNIV UTRECHT HOSP, DEPT DERMATOL, DERMATO ALLERGOL UNIT, 3508 GA UTRECHT, NETHERLANDS

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 08期

关键词：

D O I：

10.1016/0167-5699(95)80005-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allergen-specific IgE antibodies are responsible for the generation of immediate-type hypersensitivity reactions. However, its described here by Geert Mudde, Roy Bheekha and Carla Bruijnzeel-Koomen, IgE may also be involved in the uptake and processing of allergens. Such IgE-mediated antigen presentation may lend to a continuous (over)activation of the immune system due to high titers of IgE and the presence of large numbers of allergen-specific Th2 cells. In addition, it may be a cause for the advance of disease from a 'single allergy' to 'multi-allergy' syndrome.

引用

页码：380 / 383

页数：4

共 41 条

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