PREVALENCE OF INCIDENTAL THYROID-DISEASE IN A RELATIVELY LOW IODINE INTAKE AREA

被引:62
作者
TOMIMORI, E [1 ]
PEDRINOLA, F [1 ]
CAVALIERE, H [1 ]
KNOBEL, M [1 ]
MEDEIROSNETO, G [1 ]
机构
[1] UNIV SAO PAULO,HOSP CLIN,SCH MED,DIV ENDOCRINE,THYROID LAB,THYROID UNIT,BR-05403900 SAO PAULO,BRAZIL
关键词
D O I
10.1089/thy.1995.5.273
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
An ultrasonographic survey of thyroid abnormalities was conducted in 547 consecutive apparently normal overweight subjects (380 females and 167 males), aged 27-58 years in an urban area with relatively low iodine intake (mean daily urinary iodine excretion: 10.6 mu g/dL). Individuals with any previous thyroid disease or familial thyroid pathology were excluded. In 240 subjects (44%) high resolution ultrasonography of the thyroid was considered normal, In 307 individuals (56%) abnormalities of the echo structure (39%) or thyroid nodular disease (17%) were detected by ultrasonography, Marked heterogeneity of the echo structure that was considered suggestive of chronic autoimmune thyroiditis was present in 81 subjects (15%). In 72 of these patients the serum anti-TPO levels were positive by a sensitive RIA, Thyroid nodules either solid or predominantly cystic were present in 90 subjects (17%). Eighteen patients had a relatively large nodule (diameter 15-48 mm), Eleven of these nodules were missed at clinical examination. Fine needle aspiration cytology was performed in 14 patients and 7 individuals underwent thyroid surgery. In 6 subjects the pathologic diagnosis was benign adenomatous goiter and one patient had a follicular carcinoma. Thyroid function studies confirmed subclinical hypothyroidism in 27 patients (4.9%), all of them with elevated serum anti-TPO autoantibodies levels, It was concluded that the overall occurrence of thyroid disease is more common than suspected by clinical examination.
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页码:273 / 276
页数:4
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