CROSS-REACTIVITY BETWEEN DERMATOPHAGOIDES SIBONEY AND OTHER HOUSE-DUST MITE ALLERGENS IN SENSITIZED ASTHMATIC-PATIENTS

被引:25
作者
FERRANDIZ, R [1 ]
CASAS, R [1 ]
DREBORG, S [1 ]
EINARSSON, R [1 ]
FERNANDEZ, B [1 ]
机构
[1] NATL CTR BIOPROD, DEPT ALLERGENS, HAVANA, CUBA
关键词
DERMATOPHAGOIDES SIBONEY; DERMATOPHAGOIDES PTERNOYSSINUS; DERMATOPHAGOIDES FARINAE; BLOMIA TROPICALIS; STORAGE MITES; CROSS-REACTIVITY; INHIBITION; IGE;
D O I
10.1111/j.1365-2222.1995.tb00394.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background The role of Pyroglyphid mites in IgE-mediated sensitization has been well established Although mites belonging to the genus Dermatophagoides dominate in the acarofauna of domestic dust, non-pyroglyphid mites might also be of clinical importance. In Cuba, Dermatophagoides siboney is found in dust coexisting with D. pteronyssinus and Blomia tropicalis. Dermatophagoides farinae is not found. Storage mites, such as Acarus sire, Lepidoglyphus destructor and Tyrophagus putrescentiae, might also be present. Objectives The aim of this study was to investigate the allergenic relationships among the mites present in the environment of allergic patients in Cuba. Methods The crossreactivity between an extract of D. siboney and the above mentioned six mites was studied by specific IgE inhibition, using sera of mite-sensitive patients after incubation with serial dilutions of D. siboney. Results The inhibitory effect of D. siboney extract was more pronounced against D. farinae, 91%, than against D. pteronyssinus, 62%. Specific IgE to B. tropicalis, A. sire, L. destructor and T. putrescentiae were inhibited to a much lesser extent, i.e. between 47 and 58%. The correlation between IgE to D. siboney and IgE to D. pteronyssinus and D. farinae was of 0.92 and 0.90, respectively. A weaker correlation was found between D. siboney and L. destructor (0.7), A. siro (0.67), B. tropicalis (0.54) and T. putrescentiae (0.51). Conclusion Thus, D. siboney seems to be most closely related to D. farinae.
引用
收藏
页码:929 / 934
页数:6
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