DETERMINATION OF AMOXICILLIN IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION AFTER ONLINE OXIDATION

被引：30

作者：

MASCHER, H

KIKUTA, C

机构：

[1] Pharm-Analyt Lab. GmbH, Wienerstrasse 37, P.O. Box 4

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 506卷

关键词：

D O I：

10.1016/S0021-9673(01)91597-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simplified high-performance liquid chromatographic method for the determination of amoxicillin in plasma is described. Specific and sensitive fluorescence detection was achieved by on-line post-column electrochemical oxidation, using an electrochemical detector. Owing to the high specificity of the detection system, deproteinized plasma samples could be injected directly without prior treatment. This method permits a very fast and reproducible determination of amoxicillin in plasma on a routine basis at levels, down to 50 ng/ml. The absolute detection limit is about 10 pg injected. © 1990.

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页码：417 / 421

页数：5

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