TREATMENT OF STEROID-RESISTANT RENAL-ALLOGRAFT REJECTION WITH OKT-3 AND PLASMAPHERESIS

被引：7

作者：

HABERAL, M

BULUT, O

SERT, S

GULAY, H

ARSLAN, G

GUNGEN, Y

HAMALOGLU, E

ALTUNKAN, S

BILGIN, N

机构：

[1] Turkish Transplantation, Burn Foundation Hospital Ankara

来源：

RENAL FAILURE | 1991年 / 13卷 / 01期

关键词：

OKT3; PLASMAPHERESIS; REJECTION; RENAL TRANSPLANTATION;

D O I：

10.3109/08860229109022146

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The murine monoclonal antibody (OKT-3) and plasmapheresis therapy were applied in combination to treat acute renal allograft rejection in 31 patients who were not responsive to conventional bolus steroid treatment. Six of them were living related but ABO incompatible; another 25 patients were ABO compatible (1 was from a cadaver, 7 were from living unrelated donors, and 17 were from living related donors). Of these 31 patients, 25 (80.65%) showed perfect improvement in their graft function. These 25 patients had a mean follow-up time of 8 months, and had mean creatinine values of 1.2 mg % (0.8-2.8 mg %). It is concluded that OKT-3 and plasmapheresis combination therapy is very effective in reversing steroid-resistant rejections in high-risk patients such as ABO-incompatible cases.

引用

页码：43 / 47

页数：5

共 7 条

[1]

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[2]

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[3]

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[4]

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[5]

Thistlethwaite J.R., Haag B.W., Gaber A.O., Et al., The use of OKT-3 to treat steroid-resistant renal allograft rejection in patients receiving cyclosporin, Transplant Proc, 1, pp. 191-1904, (1987)

[6]

Thistlewaite J.R., Gaber A.O., Haag B.W., Et al., OKT-3 treatment of steroid-resistant renal allograft rejection, Transplantation, 2, pp. 176-184, (1987)

[7]

Norman D.J., Barry J.M., Henell K., Et al., Reversal of acute allograft rejection with monoclonal antibody, Transplant Proc, 17, (1985)

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