REDUCED SUSCEPTIBILITY TO SEIZURES IN CARBONIC ANHYDRASE-II DEFICIENT MUTANT MICE

被引:20
作者
VELISEK, L
MOSHE, SL
XU, SG
CAMMER, W
机构
[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROL,JACK & PEARL RESNICK CAMPUS,1300 MORRIS PK AVE,BRONX,NY 10461
[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT,BRONX,NY 10461
[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461
关键词
D O I
10.1016/0920-1211(93)90016-Z
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The seizure susceptibility of carbonic anhydrase II (CA) deficient mice and their normal littermates was determined and compared. In flurothyl-induced seizures, CA deficient mice displayed longer latencies to the onset of both clonic and tonic-clonic seizures. In pentylenetetrazole-induced seizures mutant mice exhibited a lower incidence of clonic seizures than did their normal littermates. Acetazolamide (a CA blocker) was used for the pretreatment of normal mice to compare them to CA deficient littermates. The pretreated mice displayed a lower incidence of flurothyl-induced tonic-clonic seizures and of both types of pentylenetetrazole seizures. The attempts to elicit audiogenic seizure did not reveal any difference between normal and mutant littermates. However, when the mice were primed by a loud sound during the critical period and retested for audiogenic seizures again at age 1.5 months, the CA deficient mice displayed a significantly lower incidence of seizures. The similarity between the anticonvulsant action of CA deficiency and the anticonvulsant action of acetazolamide suggests an important role of CA in seizures. The exact mechanism of anticonvulsant action by CA inhibition, however, remains to be elucidated.
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页码:115 / 121
页数:7
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