ISOLATION AND STRUCTURE ELUCIDATION OF A NOVEL PRODUCT OF THE ACIDIC DEGRADATION OF CEFACLOR

被引：15

作者：

BAERTSCHI, SW

DORMAN, DE

OCCOLOWITZ, JL

SPANGLE, LA

COLLINS, MW

WILDFEUER, ME

LORENZ, LJ

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1993年 / 82卷 / 06期

关键词：

D O I：

10.1002/jps.2600820616

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The acidic aqueous degradation of cefaclor, an orally administered cephalosporin antibiotic, has been investigated. The most prominent peak in the high-performance liquid chromatography profile of a degraded solution of cefaclor was isolated by preparative high-performance liquid chromatography. Mechanistically, the formation of this degradent from cefaclor involves a condensation of two cefaclor degradation products in which both products have undergone contraction from a six-membered cephem ring to a five-membered thiazole ring, presumably via a common episulfonium ion intermediate.

引用

页码：622 / 626

页数：5

共 16 条

[1]

Bundgaard, 1977, ARCH PHARM CHEMI SCI, V5, P149

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