POTENT INHIBITION OF HEPATITIS-B VIRUS PRODUCTION INVITRO BY MODIFIED PYRIMIDINE NUCLEOSIDES

被引:25
作者
MATTHES, E
LANGEN, P
VONJANTALIPINSKI, M
WILL, H
SCHRODER, HC
MERZ, H
WEILER, BE
MULLER, WEG
机构
[1] UNIV MAINZ,INST PHYSIOL CHEM,ANGEW MOLEK BIOL ABT,DUESBERGWEG 6,W-6500 MAINZ,GERMANY
[2] ACAD SCI GDR,ZENT INST MOLEK BIOL,O-1115 BERLIN,GERMANY
[3] MAX PLANCK INST BIOCHEM,W-8033 MARTINSRIED,GERMANY
关键词
D O I
10.1128/AAC.34.10.1986
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
2',3'-Dideoxy-3'-fluorothymidine (FddThd), 2',3'-didehydro-2',3'-dideoxythymidine (ddeThd), and 3'-fluoro-5-methyl-deoxycytidine (FddMeCyt) are, in their triphosphate forms, selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase. We report that 0.3 μM FddThd, FddMeCyt, or ddeThd as well as 3'-chloro-5-methyl-deoxycytidine (ClddMeCyt) or 3'-amino-5-methyl-deoxycytidine (AddMeCyt) almost completely blocked production of hepatitis B virus (HBV) particles by HBV DNA-transfected cell line 2.2.15 in vitro. Only at an at least 10-fold-higher concentration was a cytotoxic effect observed. These results indicate that FddThd, FddMeCyt, ClddMeCyt, AddMeCyt, and ddeThd are potent anti-HBV agents in vitro.
引用
收藏
页码:1986 / 1990
页数:5
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