IL-2 INDUCES TRANSIENT AND SPECIFIC DECREASE IN CYTOSOLIC PROTEIN PHOSPHATASE PP1 ACTIVITY IN MURINE T-CELL LINES

被引：9

作者：

MATSUZAWA, S ^{[1
]}

MATSUDA, A ^{[1
]}

MIZUNO, Y ^{[1
]}

KIKUCHI, K ^{[1
]}

机构：

[1] HOKKAIDO UNIV,INST IMMUNOL SCI,BIOCHEM SECT,KITA 15,NISHI-7,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 195卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2142

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the IL-2-dependent murine cytotoxic T cell line CTLL-2, IL-2 induced a rapid and transient decrease in Co2+-trypsin-treated activity of protein phosphatase PP1. The PP1 activity declined to a minimum level, being 70% of control value, in 20 min after the addition of IL-2 but recovered to the control level within 45 min. The decrease of PP1 activity was dependent on IL-2 concentration and occurred specifically in cytosolic fraction. Similar alteration was observed in IL-2 sensitive murine T-lymphoblasts. Neither activity of protein phosphatase PP2A nor PP2C showed alteration during the IL-2 stimulation. These results suggest that PP1 plays an important role in early events of the intracellular growth signaling from the IL-2 receptor. © 1993 Acdamic Press. Inc.

引用

页码：989 / 996

页数：8

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