AFFECT OF SPLEEN AND SNAKE-VENOM PHOSPHODIESTERASES ON NUCLEOTIDES CONTAINING NUCLEOSIDES IN SYN CONFORMATION

被引：14

作者：

OGILVIE, KK

HRUSKA, FH

机构：

[1] MCGILL UNIV, DEPT CHEM, MONTREAL H3C 3G1, QUEBEC, CANADA

[2] UNIV MANITOBA, DEPT CHEM, WINNIPEG, MANITOBA, CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1976年 / 68卷 / 02期

关键词：

D O I：

10.1016/0006-291X(76)91155-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dinucleotides containing 6-methyldeoxyuridine and inosine were prepared and subjected to spleen and snake venom phosphodiesterases. Spleen enzyme degrades all nucleotides tested while snake venom causes very little degradation of nucleotides having 6-methyldeoxyuridine in the 3''-terminal position. The clear implication is that snake venom will not recognize nucleoside units in the syn conformation.

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页码：375 / 378

页数：4

相关论文

共 14 条

[1] STUDIES ON CONFORMATION OF PURINE NUCLEOSIDES AND THEIR 5'-PHOSPHATES [J].

IKEHARA, M ;

UESUGI, S ;

YOSHIDA, K .

BIOCHEMISTRY, 1972, 11 (05) :830-&

[2] POLYNUCLEOTIDES .7. SYNTHESIS OF RIBOPOLYNUCLEOTIDES CONTAINING 8-SUBSTITUTED PURINE NUCLEOTIDES BY POLYNUCLEOTIDE PHOSPHORYLASE [J].

IKEHARA, M ;

TAZAWA, I ;

FUKUI, T .

BIOCHEMISTRY, 1969, 8 (02) :736-&

[3] EXTENDED HUCKEL MOLECULAR-ORBITAL APPROACH TO STUDY OF ELECTRONIC-STRUCTURES AND BARRIERS TO SYN-ANTI INTERCONVERSION IN SYN PURINE NUCLEOSIDES [J].

JORDAN, F .

BIOPOLYMERS, 1973, 12 (02) :243-255

[4] SOME STEREOCHEMICAL REQUIREMENTS OF ESCHERICHIA-COLI RIBONUCLEIC ACID POLYMERASE - INTERACTION WITH CONFORMATIONALLY RESTRICTED RIBONUCLEOSIDE 5'-TRIPHOSPHATES-8-BROMOGUANOSINE, 8-KETOGUANOSINE, AND 6-METHYLCYTIDINE TRIPHOSPHATES [J].

KAPULER, AM ;

REICH, E .

BIOCHEMISTRY, 1971, 10 (22) :4050-&

[5] RELATIONSHIP OF MONONUCLEOTIDE AND POLYNUCLEOTIDE CONFORMATION TO CATALYSIS BY POLYNUCLEOTIDE PHOSPHORYLASE [J].

KAPULER, AM ;

MONNY, C ;

MICHELSON, AM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1970, 217 (01) :18-+

[6] A CONVENIENT METHOD FOR STEPWISE SYNTHESIS OF OLIGOTHYMIDYLATE DERIVATIVES IN LARGE-SCALE QUANTITIES [J].

LETSINGE, RL ;

OGILVIE, KK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (18) :4801-+

[7] CRYSTAL AND MOLECULAR STRUCTURE OF INOSINE [J].

MUNNS, ARI ;

TOLLIN, P .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, 1970, B 26 :1101-&

[8] TERT-BUTYLDIMETHYLSILYL GROUP AS A PROTECTING GROUP IN DEOXYNUCLEOSIDES [J].

OGILVIE, KK .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1973, 51 (22) :3799-3807

[9]

RALPH RK, 1963, J AM CHEM SOC, V85, P1988

[10]

RAZZELL WE, 1961, J BIOL CHEM, V236, P1144