DUODENAL DISAPPEARANCE RATE OF ACID DURING INHIBITION OF MUCOSAL BICARBONATE SECRETION

被引:6
作者
AINSWORTH, MA
KJELDSEN, J
OLSEN, O
CHRISTENSEN, P
DEMUCKADELL, OBS
机构
[1] RIGSHOSP,DEPT SURG C,DK-2100 COPENHAGEN,DENMARK
[2] UNIV COPENHAGEN,DEPT EXPTL MED,DK-1168 COPENHAGEN,DENMARK
关键词
ACID; BICARBONATE; DUODENUM; PROSTAGLANDINS; SECRETIN;
D O I
10.1159/000200486
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
In order to investigate the relation between duodenal mucosal and pancreaticobiliary bicarbonate secretion, we have studied the effect of inhibition of mucosal bicarbonate secretion by indomethacin on the disappearance rate of acid and the concomitant plasma secretion concentrations. 10 healthy subjects were studied twice, with and without indomethacin pretreatment. By means of a double-lumen tube the duodenum was perfused with increasing amounts of acid (0, 3.0, 6.0 and 9.5 mmol/h) and the disappearence rate of acid, pH of duodenal aspirate and plasma secretin were measured. In both experiments nearly all acid, even at the highest acid load, disappeared (pH > 6). Inhibition of the duodenal mucosal bicarbonate secretion did not decrease the acid-neutralizing capacity of the human duodenum. In fact, the disappearance rate of acid at the highest acid load was a little greater when mucosal bicarbonate secretion had been inhibited than when not (10.3 +/- 0.5 vs. 9.2 +/- 0.2 mmol/h). The pancreaticobiliary secretion of bicarbonate, as judged by plasma secretin concentrations, increased, however, earlier when mucosal bicarbonate secretion had been inhibited than when not (3.7 vs. 3.0 pmol/l at an acid load of 6.0 mmol/h). This indicates that bicarbonate from the duodenal mucosa normally plays a role in the lumen neutralization of acid in the human duodenum.
引用
收藏
页码:121 / 129
页数:9
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