GENETIC-MAPPING ON THE MOUSE X-CHROMOSOME OF HUMAN CDNA CLONES FOR THE FRAGILE-X AND HUNTER SYNDROMES

被引：8

作者：

FAUST, CJ

VERKERK, AJMH

WILSON, PJ

MORRIS, CP

HOPWOOD, JJ

OOSTRA, BA

HERMAN, GE

机构：

[1] BAYLOR COLL MED,INST MOLEC GENET,1 BAYLOR PLAZA,HOUSTON,TX 77030

[2] BAYLOR COLL MED,DEPT PEDIAT,HOUSTON,TX 77030

[3] ERASMUS UNIV,DEPT CELL BIOL,3000 DR ROTTERDAM,NETHERLANDS

[4] ERASMUS UNIV,DEPT CLIN GENET,3000 DR ROTTERDAM,NETHERLANDS

[5] ADELAIDE CHILDRENS HOSP INC,DEPT CHEM PATHOL,LYSOSOMAL DIS RES UNIT,ADELAIDE,SA 5006,AUSTRALIA

来源：

GENOMICS | 1992年 / 12卷 / 04期

关键词：

D O I：

10.1016/0888-7543(92)90314-I

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Murine X-linked genes corresponding to the human Fragile X (FMR1) and Hunter syndrome (IDS) loci have been mapped in an interspecific backcross between B6CBA-Aw-J A-Bpa and Mus spretus using human cDNA clones. Pedigree analysis of recombinants from a total of 248 backcross progeny favors a gene order of (Cf-9, Mcf-2)-(Fmr-1)-Ids-Gabra3-Rsvp. Gene order is conserved between the species, although no fragile site has been detected in the mouse in this region of the murine X chromosome. © 1992.

引用

页码：814 / 817

页数：4

共 24 条

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