THYROXINE-BINDING PREALBUMIN GENE POLYMORPHISM - A POPULATION STUDY

被引：8

作者：

AKBARI, MT ^{[1
]}

FITCH, NJ ^{[1
]}

FARMER, M ^{[1
]}

DOCHERTY, K ^{[1
]}

SHEPPARD, MC ^{[1
]}

RAMSDEN, DB ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,QUEEN ELIZABETH HOSP,DEPT MED,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND

来源：

CLINICAL ENDOCRINOLOGY | 1990年 / 33卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1111/j.1365-2265.1990.tb00478.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The human thyroxine‐binding prealbumin (TBPA) gene was examined for restriction fragment length polymorphism (RFLP) in normal subjects and a subject with euthyroid hyperthyroxinaemia, due to increased thyroxine binding by TBPA, using 16 restriction enzymes. Only Taq I and Msp I were shown to detect RFLPs. In a male of the normal population and one of his daughters, an additional Taq I site was found in the 3|M′‐flanking region of the TBPA gene. The RFLP in a subject with euthyroid hyperthyroxinaemia was due to the deletion of a MspI site. All three subjects with RFLPs were heterozygous. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：155 / 160

页数：6

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