A SIDEROPHORE PRODUCTION MUTANT OF BORDETELLA-BRONCHISEPTICA CANNOT USE LACTOFERRIN AS AN IRON SOURCE

被引：9

作者：

FOSTER, LAA ^{[1
]}

DYER, DW ^{[1
]}

机构：

[1] SUNY Buffalo, SCH MED & BIOMED SCI, DEPT MICROBIOL, BUFFALO, NY 14214 USA

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 06期

关键词：

D O I：

10.1128/IAI.61.6.2698-2702.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bordetella bronchiseptica secreted a hydroxamate siderophore when grown in Fe-depleted medium. A Tn5lac insertion mutant of B. bronchiseptica, DBB22, did not produce this hydroxamate siderophore and was incapable of using lactoferrin as an Fe source. Our data suggest that B. bronchiseptica uses a siderophore for removal of Fe from lactoferrin and transferrin rather than relying upon a receptor for these host Fe-binding proteins.

引用

页码：2698 / 2702

页数：5

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