TOXICITY OF CRYOPROTECTIVE AGENTS AT 30 DEGREES

被引：13

作者：

KAROW, AM

CARRIER, O

CLOWER, BR

机构：

[1] Departments of Pharmacology and Anatomy, University of Mississippi Medical Center, Jackson, Mississippi

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1968年 / 20卷 / 04期

关键词：

D O I：

10.1111/j.2042-7158.1968.tb09742.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The toxicity of four cryoprotective agents (glycerol, dimethylsulfoxide, dextran, magnesium ion) as a function of time was assessed at 30° on isolated rabbit atria. Glycerol, 2·0 M, in Ringer solution killed all atria in less than 30 min. Atria tolerated 2·1 M dimethylsulphoxide in Ringer for 1 hr, 0·7 M glycerol in Ringer for 4 hr, 6% (w/v) dextran in saline for 6 hr and 6·6 times 10−2 M magnesium chloride in Ringer for 8 hr. After washing out the cryoprotective agents the tissue was examined histologically and for its response to isoprenaline, MJ‐1999 [4,2‐(isopropylamino‐10‐hydroxyethyl)methanesulphonilide, a β‐blocking agent] and isoprenaline and ouabain. These tests were the more sensitive indicators of functional integrity. 1968 Royal Pharmaceutical Society of Great Britain

引用

页码：297 / &

共 8 条

[1] EFFECT OF DIMETHYL SULFOXIDE ON MYOCARDIUM DURING HYPOTHERMIC PRESERVATION OF HEART [J].