PRODUCTION OF CARRIER-FREE GA-66 AND LABELING OF ANTIMYOSIN ANTIBODY FOR POSITRON IMAGING OF ACUTE MYOCARDIAL-INFARCTION

被引：18

作者：

GOETHALS, P

COENE, M

SLEGERS, G

VOGELAERS, D

EVERAERT, J

LEMAHIEU, I

COLARDYN, F

HEYNDRICKX, GR

机构：

[1] STATE UNIV GHENT HOSP,FAC PHARMACEUT SCI,ANALYT CHEM LAB,B-9000 GHENT,BELGIUM

[2] STATE UNIV GHENT HOSP,INTENS CARE UNIT,B-9000 GHENT,BELGIUM

[3] STATE UNIV GHENT,DEPT PHYSIOL,B-9000 GHENT,BELGIUM

[4] STATE UNIV GHENT,ELECTR & METROL LAB,B-9000 GHENT,BELGIUM

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1990年 / 16卷 / 4-6期

关键词：

!sup]66[!/sup]Ga production; Antimyosin monoclonal antibodies; Myocardial necrosis; Positron emission tomography (PET);

D O I：

10.1007/BF00842774

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A method for labeling monoclonal antimyosin antibodies with66Ga is described. The radionuclide is a positron emitter (t1/2: 9.4 h) produced by means of the63Cu (4He, n)66Ga reaction. Purification of the66Ga from the copper target is described in detail. Monoclonal antimyosin antibodies are labeled with66Ga at a high yield (99%) by transcomplexation from an acetate buffer with the diethylenetriamine pentaacetic acid (DTPA)-labeled antibody and preliminary evaluated in two dogs for imaging of myocardial necrosis by positron emission tomography. © 1990 Springer-Verlag.

引用

页码：237 / 240

页数：4

共 12 条

[1]

GOETHALS P, 1987, Nuklearmedizin, V26, P171

[2] CYCLOTRON PRODUCTION OF CARRIER-FREE GA-66 AS A POSITRON EMITTING LABEL OF ALBUMIN COLLOIDS FOR CLINICAL USE [J].