REJECTION OF CLASS-I MHC-DEFICIENT HEMATOPOIETIC-CELLS BY IRRADIATED MHC-MATCHED MICE

被引:376
作者
BIX, M
LIAO, NS
ZIJLSTRA, M
LORING, J
JAENISCH, R
RAULET, D
机构
[1] MIT,CTR CANC RES,CAMBRIDGE,MA 02139
[2] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
[3] MIT,DEPT BIOL,CAMBRIDGE,MA 02142
[4] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142
关键词
D O I
10.1038/349329a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
IRRADIATED MHC-heterozygous mice often reject bone marrow cells transplanted from one of the homozygous parental strains, a phenomenon ('hybrid resistance') that appears to violate the laws of transplantation 1,2. Rejection of parental and allogeneic marrow cells also differs from conventional T cell-mediated rejection mechanisms as it is effected by NK1.1+ cells 3-5. To account for the unusual specificity of bone marrow rejection, it has been proposed that NK1.1+ cells destroy marrow cells that fail to express the full complement of self MHC class I (MHC-I) molecules 5. We show here that NK1.1+ cells in normal mice reject haemopoietic transplants from mice that are deficient for normal cell-surface MHC-I expression because of a targeted mutation in the beta-2-microglobulin gene 6-9. These findings demonstrate that deficient expression of MHC-I molecules renders marrow cells susceptible to rejection.
引用
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页码:329 / 331
页数:3
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