ZN-65 ABSORPTION IN PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS ASSESSED BY WHOLE-BODY COUNTING TECHNIQUE

被引：19

作者：

KIILERICH, S

HVIDJACOBSEN, K

VAAG, A

SORENSEN, SS

机构：

[1] HERLEV HOSP,DEPT CLIN PHYSIOL & NUCL MED,DK-2730 HERLEV,DENMARK

[2] HERLEV HOSP,DEPT MED,DK-2730 HERLEV,DENMARK

[3] RIGSHOSP,DEPT CLIN PHYSIOL & NUCL MED,DK-2100 COPENHAGEN,DENMARK

来源：

CLINICA CHIMICA ACTA | 1990年 / 189卷 / 01期

关键词：

Diabetes mellitus; Zinc; Zinc absorption;

D O I：

10.1016/0009-8981(90)90229-L

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The gastrointestinal absorption of zinc was measured in patients with insulin-dependent diabetes mellitus. The concentration of zinc in serum was similar to healthy individuals. However the urinary excretion rate of zinc relative to the creatinine excretion, was approximately doubled (p < 0.001) in the diabetics. The absorption of 65Zn tended to be lower in diabetics, but did not reach the level of statistical significance (retention percent 30.6 versus 42.6 (p > 0.10). A hypothesis of intracellular zinc depletion with time in insulin-dependent diabetics is proposed. © 1990.

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收藏

页码：13 / 18

页数：6

相关论文

共 14 条

[1] EFFECTS OF ZINC ION ON CONFORMATION OF ANTIGENIC DETERMINANTS ON INSULIN [J].

ARQUILLA, ER ;

THIENE, P ;

BRUGMAN, T ;

RUESS, W ;

SUGIYAMA, R .

BIOCHEMICAL JOURNAL, 1978, 175 (01) :289-297

[2] EFFECT OF ZINC ON INSULIN METABOLISM [J].

ARQUILLA, ER ;

PACKER, S ;

TARMAS, W ;

MIYAMOTO, S .

ENDOCRINOLOGY, 1978, 103 (04) :1440-1449

[3] INSULIN-LIKE EFFECT OF ZINC ON ADIPOCYTES [J].

COULSTON, L ;

DANDONA, P .

DIABETES, 1980, 29 (08) :665-667

[4] ABNORMAL ZINC-METABOLISM IN TYPE-II DIABETES-MELLITUS [J].

FITZHARRIS, JW .

AMERICAN JOURNAL OF MEDICINE, 1984, 76 (06) :A60-&

[5] CRYSTAL STRUCTURE OF INSULIN .2. AN INVESTIGATION OF RHOMBOHEDRAL ZINC INSULIN CRYSTALS AND A REPORT OF OTHER CRYSTALLINE FORMS [J].

HARDING, MM ;

HODGKIN, DC ;

KENNEDY, AF ;

OCONNOR, A ;

WEITZMANN, PD .

JOURNAL OF MOLECULAR BIOLOGY, 1966, 16 (01) :212-+

[6] DETERMINATION OF ZINC IN SERUM AND URINE BY ATOMIC-ABSORPTION SPECTROPHOTOMETRY - RELATIONSHIP BETWEEN SERUM LEVELS OF ZINC AND PROTEINS IN 104 NORMAL SUBJECTS [J].

KIILERICH, S ;

CHRISTENSEN, MS ;

NAESTOFT, J ;

CHRISTIANSEN, C .

CLINICA CHIMICA ACTA, 1980, 105 (02) :231-239

[7] ABNORMAL ZINC-METABOLISM IN TYPE-II DIABETES-MELLITUS [J].

KINLAW, WB ;

LEVINE, AS ;

MORLEY, JE ;

SILVIS, SE ;

MCCLAIN, CJ .

AMERICAN JOURNAL OF MEDICINE, 1983, 75 (02) :273-277

[8] HYPERZINCURIA IN INSULIN TREATED DIABETES-MELLITUS - ITS RELATION TO GLUCOSE-HOMEOSTASIS AND INSULIN ADMINISTRATION [J].

MCNAIR, P ;

KIILERICH, S ;

CHRISTIANSEN, C ;

CHRISTENSEN, MS ;

MADSBAD, S ;

TRANSBOL, I .

CLINICA CHIMICA ACTA, 1981, 112 (03) :343-348

[9] DEVELOPMENT OF BONE-MINERAL LOSS IN INSULIN-TREATED DIABETES - A 1-1/2 YEARS FOLLOW-UP-STUDY IN 60 PATIENTS [J].

MCNAIR, P ;

CHRISTIANSEN, C ;

CHRISTENSEN, MS ;

MADSBAD, S ;

FABER, OK ;

BINDER, C ;

TRANSBOL, I .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1981, 11 (01) :55-59

[10] INSULIN BINDING IN DIABETES - RELATIONSHIPS WITH PLASMA-INSULIN LEVELS AND INSULIN SENSITIVITY [J].

OLEFSKY, JM ;

REAVEN, GM .

DIABETES, 1977, 26 (07) :680-688