EVALUATION OF A BILAYER ARTIFICIAL SKIN CAPABLE OF SUSTAINED-RELEASE OF AN ANTIBIOTIC

被引：49

作者：

MATSUDA, K ^{[1
]}

SUZUKI, S ^{[1
]}

ISSHIKI, N ^{[1
]}

YOSHIOKA, K ^{[1
]}

WADA, R ^{[1
]}

HYON, SH ^{[1
]}

IKADA, Y ^{[1
]}

机构：

[1] KYOTO UNIV,BIOMED ENGN RES CTR,KYOTO 606,JAPAN

来源：

BIOMATERIALS | 1992年 / 13卷 / 02期

关键词：

WOUND DRESSINGS; ANTIBIOTICS; DRUG DELIVERY;

D O I：

10.1016/0142-9612(92)90007-B

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A bilayer artificial skin, composed of an upper silicone sheet and a lower collagen sponge, has been developed by modifying a technique proposed by Yannas and Burke. We have applied it clinically with success, but infection sometimes occurred in the area where the artificial skin was placed. To use it safely in an infected wound, we developed a new type of artificial skin capable of sustained release of antibiotic. Microspheres of poly-L-lactic acid containing an antibiotic, were installed in the upper silicone sheet. The usefulness of the new type of artificial skin was suggested by in vitro studies.

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页码：119 / 122

页数：4

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